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M94A3183.TXT
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1994-10-25
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Document 3183
DOCN M94A3183
TI HTLV-I among native people of far eastern regions of Russia.
DT 9412
AU Gurtsevitch V; Senyuta N; Stepina V; Yakovleva L; Syrcev A; Susova O;
Pavlish O; Cancer Research Center, Moscow, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):134 (abstract no. PA0156). Unique
Identifier : AIDSLINE ICA10/94369392
AB OBJECTIVE: To study HTLV-I prevalence among native people inhabiting Far
Eastern Russia with special attention to Nivkhi people from Sakhalin
intimately connected with Ainu people before 1945. The latters revealed
high level of HTLV-I seroprevalence when have been tested in Hokkaido.
METHODS: Two commercial screening tests as well as various confirmatory
assays including WPs with recombinant gp46 env and p40 tax and PCR
analysis were used to detect HTLV-I carriers. PCR was also employed to
discriminate between HTLV-I and HTLV-II. RESULTS: 16 of 1809 native
individuals tested were finally recognized as HTLV-I positive. Among
them 14 were representatives of Nivkhi people (2.25%), 1--Orochi people
(1.2%) and 1--Negidalian people (1%). The other 6 groups of native
people were found to be negative. Important, 13 of 14 HTLV-I infected
Nivkhi people were inhbitants of the same settlement (Nogliki) in
Sakhalin (5.2%). Experiments indicated that HTLV-I rather than HTLV-II
is present in infected individuals. CONCLUSIONS: This study clearly
demonstrates that: a) Nivkhi people are most HTLV-I infected among
different natives inhabiting Far Eastern regions of Russia, b) a cluster
of HTLV-I infection is present among Nivkhi people in Sakhalin; and d)
HTLV-I infected Nivkhi people revealed unusual pattern of virus-specific
antibodies consisting in discrepancy between low immune response and
high PCR positivity level.
DE Carrier State/EPIDEMIOLOGY Cluster Analysis Comparative Study
Demography Diagnosis, Differential Ethnic Groups Human
HTLV-I/ISOLATION & PURIF HTLV-I Infections/DIAGNOSIS/*EPIDEMIOLOGY
HTLV-II/ISOLATION & PURIF HTLV-II Infections/DIAGNOSIS/EPIDEMIOLOGY
Polymerase Chain Reaction/METHODS Prevalence Russia/EPIDEMIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).